{"id":483,"date":"2018-06-14T16:31:45","date_gmt":"2018-06-14T16:31:45","guid":{"rendered":"https:\/\/kambodawn.com\/?page_id=483"},"modified":"2020-07-07T18:40:33","modified_gmt":"2020-07-07T18:40:33","slug":"kambo-science","status":"publish","type":"page","link":"https:\/\/kambodawn.com\/?page_id=483","title":{"rendered":"Kambo Pharmacology"},"content":{"rendered":"

\"\"<\/a>Vittorio Erspamer of the University of Rome, an Italian pharmacologist, and chemist, known for the\u00a0identification, synthesis and pharmacological studies of more than sixty new\u00a0chemical compounds was the first to analyze Kamb\u00f4 in the laboratory. \u00a0He was twice nominated for a Nobel prize and was also responsible for first discovering the well-known neurotransmitters serotonin and octopamine.<\/p>\n

Dr Erepamer, described the\u00a0Phyllomedusa\u00a0<\/em>genus as a \u201ctreasure trove\u201d of bioactive peptides which are short chains of amino acids that bind to human cell receptors. The secretion of P. bicolor\u00a0<\/em>in particular contains dozens of peptides, most significantly including Phyllocaerulein, Phyllokinin, Phyllomedusin, Phyllolitorin, Dermorphin, Tryptophyllins, Deltorphin, Dermaseptin and Adenoregulin (Dermaseptin B2).<\/p>\n

Peptides in\u00a0Kamb\u00f4<\/h4>\n

Some of the neuropeptides contained in the secretion of the\u00a0Phyllomedusa bicolor<\/em>\u00a0and some of their applications.<\/p>\n

Phyllocaerulein<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(Caeruleins family)<\/em><\/p>\n

Phyllocaerulein is a hypotensive neuropeptide that stimulates the adrenal cortex and pituitary gland. Present in Kambo at around 32 micrograms per milligram.\u00a0<\/p>\n

Phyllocaerulein also reduces blood pressure, modifies satiety, sedation, and thermoregulation. It is also a potent analgesic. Stimulates the adrenal cortex and the pituitary gland, contributing to heightened sensory perception and increased stamina.<\/p>\n

Phyllokinin<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(Bradykinins family)<\/em><\/p>\n

Hypotension \u2013 a long-lasting reduction in blood pressure. Potent vessel dilator, increasing the permeability of the blood-brain barrier.<\/p>\n

Phyllokinin relaxes smooth muscles and is\u00a0present in Kambo at around 18 micrograms per milligram.<\/p>\n

Phyllomedusin<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(Tachykinins family)<\/em><\/p>\n

Phyllomedusin, a neuropeptide, interacts with tachykinin receptors\u2014shown to regulate the functions of dopamine, serotonin, and other neurotransmitters.\u00a0 Phyllomedusin contracts smooth muscles strongly affecting the intestines and bowels, which contributes to deep purging of toxins.\u00a0 The fast dilation of the blood vessels causes the \u2018rushing\u2019 or \u201cpounding\u2019 sensation that Kamb\u00f4 Sometimes produces.<\/p>\n

Phyllomedusin is a potent vasodilator, the increases the permeability of the blood-brain barrier. It is present in Kambo at around 22 micrograms per milligram.<\/p>\n

Phyllolitorin<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(Bombesins family)<\/em><\/p>\n

Neuropeptides that are active in the central and peripheral nervous System, Stimulate gastric acid secretion and smooth muscle contraction.<\/p>\n

Dermorphin<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(Sauvagine Family)<\/em><\/p>\n

This neuropeptide produces a powerful opiate-like activity on mu-type opioid receptors, as a potent analgesic 30-40 times more potent than Morphine. Dermorphin may also have effects on pulmonary ventilation and pituitary hormone release.<\/p>\n

It is present at 3 micrograms per milligram, functions like a hormone. It interacts with the pituitary-adrenal axis and corticotrophin-releasing receptors\u2014involved in stress, anxiety, depression, and addictive behavior.[<\/p>\n

Tryptophyllins<\/strong><\/p>\n

\"\"<\/a><\/p>\n

Recently found to be highly potent against the yeast Candida Albicans.<\/p>\n

Deltorphin<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(Porphin Family)<\/em><\/p>\n

A heptapeptide, which has a higher affinity and selectivity for delta Podbinding sites than any other natural compound known. Two Deltorphins have been discovered in the Secretion of\u00a0Phyllomedusa bicolor<\/em>.<\/p>\n

Deltorphins and Dermorphin are both powerful opioid receptor agonists. Deltorphins in particular have among the highest binding affinity and selectivity to delta opioid receptors of any natural compound. Dermorphin is highly selective for mu opioid receptors. Present at 5.2 and 0.25-0.33 micrograms per milligram, respectively, these peptides are many times more potent than endogenous beta-endorphin.<\/p>\n

Dermaseptin<\/strong>\"\"<\/a><\/p>\n

(Dermaseptin Family)<\/em><\/p>\n

Potent antimicrobial activity against bacteria, yeast, fungi, protozoa and enveloped viruses as well as various filamentous fungi that are responsible for severe opportunistic infections accompanying AIDS and the use of immunosuppressant agents.<\/p>\n

Adenoregulin<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(Dermaseptin Family)<\/em><\/p>\n

Adenoregulin (also named Dermaseptin B2) is a 33 amino acid peptide that stimulates the binding of agonists of the A1 adenosine receptors and is shown to cause behavioral depression in mice. It is a fundamental component in all human cell fuel and has shown to be very effective in killing cancer cells.<\/p>\n

Safety and Toxicity<\/h2>\n

Little is known about the long-term safety of Kambo, but evidence suggests that Deltorphin and Dermorphin may cause respiratory depression and lead to heavy reliance with frequent and prolonged use. Kambo-related deaths have also been circumstantially related to the secretion\u2019s depressive effects on the central nervous system however this has yet to be proven. Toxins present in Kambo may affect the cardiovascular system, kidneys, pancreas, and liver.<\/p>\n

Anecdotal reports warn of \u201cfrog disease,\u201d an incurable condition arising from the non-traditional use of Kambo (e.g. oral consumption, smoking, or insufflation). Apparently feeling like it\u2019s \u201ceating the brain, \u201cfrog disease\u201d is characterized by weak muscles, cardiac arrest, and death. The condition may be caused by parasitic microorganisms\u2014usually eliminated by the body\u2019s immune response to skin burns.<\/p>\n

\u00a0<\/h2>\n

Resources<\/h2>\n

IAPK Practitioner Guide (2017)<\/p>\n

Gorman, P. (1993). Making Magic. OMNI.<\/p>\n

Labate, B. C., de Lima, E. C. (2014). Medical Drug or Shamanic Power Plant: The Uses of Kambo in Brazil. Ponto Urbe, 15.<\/p>\n

Labate, B. C. (2012). The Shaman Who Turned Into a Frog: a Promise of Patented Medicine. Erowid.<\/p>\n

Labate, B. C., Jungaberle, H. (Eds.). (2011). The Internationalization of Ayahuasca. Z\u00fcrich: LIT Verlag M\u00fcnster.<\/p>\n

Milton, K. (1994). No Pain, No Game. Natural History.<\/p>\n

Daly, J. et al. (1992). Frog secretions and hunting magic in the upper Amazon: Identification of peptide that interacts with an adenosine receptor. Pharmacology, 89, 10960-10963.<\/p>\n

Erspamer, V. et al. (1993). Pharmacological Studies of \u2018Sapo\u2019 from the Frog Phyllomedusa bicolor Skin: A Drug Used by the Peruvian Matses Indians in Shamanic Hunting Practices. Toxicon, 31, 9: 1099-1111.<\/p>\n

Lattanzi, G. (nd.). Kambo: Scientific Research and Healing Treatments.<\/p>\n

Gomes, M. B. (2008). Kambo, The Spirit of the Shaman.<\/p>\n

Prada, P. (2006). Poisonous Tree Frog Could Bring Wealth to Tribe in Brazilian Amazon. The New York Times.<\/p>\n

Sumpter, L. (2015). Kambo: Nature\u2019s Vaccine For The Mind And Body.<\/p>\n\n\n

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